Researchers have grown the first ever lungs in mouse embryos

Methods used on mice are planned to be used for growing an organ in the body of the animal for further transplantation in humans. 

Organ transplants embryonic stem cells
Organ transplants embryonic stem cells

This will solve the main problem of today's transplantology - the need to wait for donor organs.

Growing organs from stem cells on synthetic scaffolds is not easy, a new lung growth strategy to grow an organ in the body of an still developing animal.

There are millions of people with incurable lung diseases who are dying from a shortage of donor organs for transplantation. 

A group of scientists from the United States and Japan have grown fully functional lungs in mouse embryos, opening up new opportunities for organ transplants in human patients. The research was published on the Columbia University website.

Considering the difficulties of other groups of scientists growing organs from stem cells on synthetic frames, the researchers have defined a new strategy for organ growth.

They suggested that it might be much easier to raise a new organ in a still developing animal.
Previously, they created conditions for the cultivation of lung tissue from donor stem cells, and then implanted them into two types of artificial mouse embryos. 

The first type was deficient in stem cells, while the second could not produce enough stem cells to form lungs. Implanted cells displaced host cells and formed fully functional lungs in the course of division.

Further tests confirmed that the lungs worked as well as normal organs throughout the life of mice.

"Stem cells were implanted before the immune system of the embryos was activated, which explains why the organ was not rejected," explained the author of the study, Munemasa Mori.
Next, the team will test the technology of growing lungs on larger models of animals. In the future, the approach will allow growing functional organs in the animal body for subsequent transplantation to humans.

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