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Researchers have Identified a Virus that Attacks Human Cancer Cells

Researchers identified a virus that attacks human cancer cells can distinguishes Healthy cells. Viruses are usually supposed to worry us, b...

Wednesday, January 16, 2019

Researchers have Identified a Virus that Attacks Human Cancer Cells

Researchers identified a virus that attacks human cancer cells can distinguishes Healthy cells.

Viruses are usually supposed to worry us, but this is not the case with inoculate viruses. those that infect cancer cells and kill them, ignoring healthy cells. So it is no wonder that the search for such viruses attracts many researchers.


picture of germs, cancer cells and a microscope


The Seneca Valley virus.


This virus also known as Senecavirus affects pigs and cows. In recent years it has found to attack human cancer cells.

The ability to identify tumors and ignore normal cells tested in two trials. The first in relapsed solid tumors in children and the second in lung carcinoma.

Experiments also found that the immune system was removing the virus from the body. Thus preventing it from completing its anticancer action.




Ongoing research to understand how the Seneca Valley virus works.


Researchers at the University of Otago in New Zealand discovered in 2017. That the virus binds to a receptor called ANTXR1, which is active in more than 60 percent of the cancers in humans.
ANTXR1, or its full name 'Anthrax Toxin Receptor 1' is a receptor that binds to the toxin molecules. This molecules released by Bacillus anthracis are the cause of Anthrax.

Turns out that this receptor appears mainly in human cancer cells. Its second version ANTXR2 appears in healthy body cells.



New study published in the PNAS journal.


Researchers have been able to understand how this virus associate with the 'sick' receptor.

They used a cryogenic electron microscope to see the link between them at a resolution of only a few atoms.

The researchers compared the structure of the two receptors. Trying to understand which part of the ANTXR1 receptor allows it to bind to the virus.

Taking 7,000 pictures, Researchers discovered amino acids. Those acids link the receptor to the virus. Which differentiates between the two receptors.


To vaccinate the virus.


The new discovery allows us to understand how the immune system identifies the virus.

The virus uses area to bind to the receptor converges with the region of the virus that the immune system antibodies identify and bind to. The immune system antibodies identify the virus. This helps researchers make changes to the structure. So that it can continue its anticancer activity without the body fighting it.

Such a move may be dangerous as it will improve the virus's ability to destroy cancer cells. But also produce a virus that is resistant to the immune system.

A possibility is the to suppress the immune system when treating the virus. But such treatment harm the ability to attack cancer with the help of the immune system.

As is currently done in immunotherapy and cancer vaccines, which aided by the natural ability to identify tumors and destroy them. Researchers need to combine creativity and discretion to develop the next drug that will end cancer.


The Seneca Valley Virus in Close To Nuclear Resolution.





The structure demonstrates how the virus binds to its cellular receptor.


The Anthrax toxin receptor. Type 1 of this particular receptor is selectively expressed in as much as 60% of human cancer cells. As well as enables the virus to infect and demolish them though not impacting healthy cells.

Research study published in the journal Proceedings of the National Academy of Sciences, USA. Show how the virus is able to identify its target and leave regular cells on its own.

OIST Scientists Utilized cryo electron microscopy to rebuild the Seneca Valley virus structure.

48 comments:

  1. why make a virus which can go out of control, use the binding part and put some other end that will get the attention of the immune system to the cancerous cell

    ReplyDelete
    Replies
    1. How would you locate every single cancer cell to do this, the whole idea behind this is that the virus can target specific cells

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    2. How would you locate every single cancer cell to do this, the whole idea behind this is that the virus can target specific cells

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